My OS is windows 10 64bit and I play fallout at lowest settings for everything besides godflare and resolution. I'm on R7 200 series 2GB VRAM, 8GB Ram, i5 6600K Processor. But anyone with 2gb of VRam or less (or even 4gb or less) will still CTD randomly. People with higher end GPUs will not experience this problem as much or at all. Even then the game will still CTD no matter what you do (5-45mins until CTD is what I get). The only way to prevent the CTD from happening as much or constantly is to lower Visual Settings EVEN MORE than you already have (IE lower distance stuff, lower resolution). AMD has not made any updates on this nor has the latest Beta 1.2.33 patch helped at all. If you're RAM can't handle all the cache that comes from the game it will cause Driver Failure.
The higher your visual settings are the more often you'll CTD even despite having 30fps. If you have a Graphics card that has VRam of 2gb or less you will CTD (Crash To Desktop).
The issue with Fallout 4 crashing so often as Bethesda already knows is a RAM / VRAM related issue due to the game's lack of optimization.
